Uptown Central Vacations from $681

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Your Uptown Vacation

Book a customized vacation package to Uptown and experience the charms of this neighborhood from dawn till dusk. From its shopping and nature to its unique personality and vibe, there are plenty of fabulous reasons to visit Uptown. Your trip to Uptown wouldn't be complete without exploring big-name attractions nearby such as San Antonio Zoo and Aquarium, San Antonio Botanical Gardens and Marion Koogler McNay Art Museum. Whatever your travel plans or the size of your budget, booking your perfect Uptown vacation is easy with Expedia.

The Latest Uptown Central Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Contessa

Hotel Contessa

Downtown San Antonio
$681
per person
Dec 17 - Dec 20
found 1 day ago
Roundtrip flight included
Chicago (CHI) to San Antonio (SAT)
9/10 Wonderful! (3,885 reviews)
Tx Home Group- San Antonio

Tx Home Group- San Antonio

Midtown
$1,021
per person
Nov 23 - Nov 29
found 1 day ago
Roundtrip flight included
Los Angeles (LAX) to San Antonio (SAT)
7.8/10 Good! (10 reviews)
Hyatt Regency Hill Country Resort and Villas

Hyatt Regency Hill Country Resort and Villas

Far West Side
Save 100% on your flight
$722
per person
Dec 4 - Dec 7
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Antonio (SAT)
8.8/10 Excellent! (1,001 reviews)
Very clean room and facilities! The room was very spacious (we had a 1 king bed room) and designed to be very homey. The lazy river and slide were the highlight for my husband and 6 year old, spent all day there with poolside food service. The lagoon was beautiful and clean, and it’s probably best for toddlers or families who want some quiet calm swim time (whereas the lazy river and slide area are more exciting). One tip about the lagoon—id say about 40% of it is roped off as a swim area near the shore, while the rest of it is for rental boating only, so my high energy 6 year was a bit disappointed that he couldn’t swim out far into the lagoon. That being said it’s a beautiful spot to relax and have some peace and quiet.

Reviewed on Sep 20, 2026

Restored Historic 2br/1.5ba House Near Downtown

Restored Historic 2br/1.5ba House Near Downtown

Near East Side
$742
per person
Dec 3 - Dec 7
found 22 hours ago
Roundtrip non-stop flight included
Minneapolis (MSP) to San Antonio (SAT)
8.2/10 Very Good! (11 reviews)
Overall very good

Reviewed on Aug 18, 2026

The St. Anthony, A Luxury Collection Hotel, San Antonio

The St. Anthony, A Luxury Collection Hotel, San Antonio

Downtown San Antonio
$836
per person
Dec 17 - Dec 20
found 1 day ago
Roundtrip flight included
Chicago (CHI) to San Antonio (SAT)
8.8/10 Excellent! (1,005 reviews)

Where to stay in Uptown Central

Find the best Uptown Central areas and neighborhoods for the activities you enjoy most. Learn more about Uptown Central
A boat tour on a canal with a bridge in the background.

Downtown San Antonio

5 out of top 10 points of interest in this area

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Find hotels in Downtown San Antonio
An old church with a bell tower and arches, surrounded by greenery and a stone structure.

Far West Side

1 out of top 10 points of interest in this area

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Find hotels in Far West Side
A cityscape with a prominent tower, a large body of water, and a sunset.

Medical Center District

While Medical Center District isn't home to many top sights, Wonderland of the Americas Mall and Huebner Oaks are some notable places to visit nearby.

Find hotels in Medical Center District
A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

While visiting Northwest Side, you might make a stop by sights like Huebner Oaks and Convocation Center.

Find hotels in Northwest Side
A vast landscape with a winding road, dense forest, and a clear blue sky.

Stone Oak

Travelers come to Stone Oak for its abundant dining options, and you can see top attractions like Shops at Hardy Oak and Alta Vista at Stone Oak while you're in town.

Find hotels in Stone Oak

Uptown Central Hotel Deals

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

143 NE Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
$80 nightly
$95 total
Sep 27 - Sep 28
Total with taxes and fees
9/10 Wonderful! (2,229 reviews)
"Horrible experience. AC was not working. Switched room three times and none of them had no ac. Several other people were experiencing the same issue. We had to leave and get a room at their sister hotel next door"

Reviewed on Sep 21, 2026

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
Wyndham Garden San Antonio Airport

Wyndham Garden San Antonio Airport

8818 Jones Maltsberger Rd San Antonio TX
Fully refundableReserve now, pay when you stay
$85 nightly
$101 total
Sep 27 - Sep 28
Total with taxes and fees
Wyndham Garden San Antonio Airport
La Quinta Inn & Suites by Wyndham San Antonio Airport

La Quinta Inn & Suites by Wyndham San Antonio Airport

850 Halm Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
$79 nightly
$94 total
Sep 27 - Sep 28
Total with taxes and fees
7.8/10 Good! (2,705 reviews)
"Staff is amazing ! The pool, hot tub were dirty. The grounds smelled like dog urine. Suggestion ? Have a doggy area away from the front and pool side of the hotel."

Reviewed on Sep 21, 2026

La Quinta Inn & Suites by Wyndham San Antonio Airport
See all 6,305 properties in Uptown Central
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Uptown Central attractions

A large, abstract sculpture with a flowing design, set against a dramatic sky.
Photo by Sarah C.

North Star Mall

8.8/10 (1,193 reviews)
You can enjoy retail therapy at North Star Mall during your visit to San Antonio. Experience the great live music and acclaimed theater scene in this walkable area.
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An art gallery with abstract paintings on the walls and a bench in the center.

Marion Koogler McNay Art Museum

8.6/10 (139 reviews)
You can spend time studying the exhibits at Marion Koogler McNay Art Museum in San Antonio. Experience the lively festivals and acclaimed art scene in this walkable area.
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Alamo Quarry Market

8.6/10 (23 reviews)
You can do some window-shopping at Alamo Quarry Market during your stay in San Antonio. Experience the acclaimed theater scene or attend a sporting event in this walkable area.
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McAllister Park

10.0/10 (1 review)
After visiting McAllister Park, make a plan to see the other sights and activities in San Antonio. Discover the top-notch restaurants and lively festivals in this walkable area.
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Ice & Golf Center at Northwoods

You can take time to visit Ice & Golf Center at Northwoods during your travels to San Antonio. Amble around this family-friendly area's riverfront or attend a sporting event.
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Quarry Golf Club

10.0/10 (1 review)
Enjoy a round of golf in San Antonio at Quarry Golf Club. Experience the great live music and acclaimed art scene in this walkable area.
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Northridge Park

10.0/10 (2 reviews)
After visiting Northridge Park, make a plan to see the other sights and activities in San Antonio. Experience the lively festivals or attend a sporting event in this walkable area.
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Harry B Orem Stadium

Catch an event at Harry B Orem Stadium during your trip to San Antonio. Experience the lively festivals or attend a sporting event in this walkable area.
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Things to do

San Antonio: Discovery Tour at Natural Bridge Caverns

San Antonio: Discovery Tour at Natural Bridge Caverns

$33
per adult
98% of travellers recommend
San Antonio: Discovery Tour at Natural Bridge Caverns
San Antonio: Botanical Garden Admission Ticket

San Antonio: Botanical Garden Admission Ticket

$18
per adult
100% of travellers recommend
San Antonio: Botanical Garden Admission Ticket
San Antonio: The DoSeum General Admission Ticket

San Antonio: The DoSeum General Admission Ticket

$18
per adult
San Antonio: The DoSeum General Admission Ticket
See all activities in San Antonio
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.